Why you should avoid Caffeine – it can make you fat, alter your DNA, and it’s toxic.

caffeine_drinks  eu_toxic_chemicals_222   coffee    toxc2

The LD50 (Lethal Dose 50%) of  caffeine is 192 mg. The lower the LD50 number, the more lethal the substance is. For comparison, Vitamin C (ascorbic acid) has an LD50 of 11,900 mg/kg. Cyanide has an LD50 of 6.4 mg/kg.


Caffeine is mutagenic for mammalian somatic cells (meaning that is alters your DNA and is passed down genetically to offspring). Mutagenic for bacteria and/or yeast. May cause damage to the following organs: heart, gastrointestinal tract, central nervous system.

It has Chronic Effects on Humans: May cause adverse reproductive effects (fetotoxicity, maternal (parnutrition) and birth defects. May affect genetic material (mutagenic). May cause cancer (tumorgenic) based on animal data.

It may cause gastrointestinal (digestive) tract irritation with epigastric pain, abdominal cramps, nausea, vomiting and diarrhea.

It affects metabolism and cardiovascular system with symptoms including flushing, palpitations, rapid heart rate, dysrhythmias, hypotension, blood pressure elevation and weight loss, metabolic acidosis.

It may affect brain and behavior/central nervous system. Symptoms may include nervousness, anxiety, restlessness, insomnia, dizziness, tremor, seizures, convulsions, hallucinations,
somnolence, toxic psychosis, tremors, convulsions, ataxia.

May also affect blood, respiration (hyperventilation), and urinary system (mild increase in urinary volume and urinary sodium excretion), and may directly produce hypokalemia.

Chronic Potential Health Effects: May cause cancer (tumorigen) based on animal studies. May cause reproductive and fetal effects. May cause digestive tract disturbances (increased gastric acid, and pepsin secretion and a decrease in lower esophogeal sphincter pressure), cardiovascular disturbances.

Caffeine also fits the definition of an addictive substance, with withdrawal symptoms, an increase in tolerance over time, and physical cravings.

Caffeine is metabolized in the liver.

It increases lipolysis, leading to elevated glycerol and free fatty acid levels in the blood plasma.

It dilates blood vessels and increases urine volume.

Caffeine crosses the blood–brain barrier that separates the bloodstream from the interior of the brain.

Caffeine acts as a nonselective antagonist of adenosine receptors. The caffeine molecule is structurally similar to adenosine, and binds to adenosine receptors on the surface of cells without activating them (an “antagonist” mechanism of action). Therefore, caffeine acts as a competitive inhibitor.

Caffeine tolerance develops very quickly, especially among heavy coffee and energy drink consumers. Complete tolerance to sleep disruption effects of caffeine develops after consuming 400 mg of caffeine 3 times a day for 7 days. Full complete tolerance of caffeine was observed when subjects consumed 750–1200 mg per day.

Withdrawal symptoms — headache, irritability, an inability to concentrate, drowsiness, insomnia and pain in the stomach, upper body, and joints — may appear within 12 to 24 hours after discontinuation of caffeine intake. This peaks at roughly 48 hours, and usually last from one to five days, representing the time required for the number of adenosine receptors in the brain to revert to “normal” levels. Analgesics, such as aspirin, can relieve the pain symptoms.

The DOT Classification of caffeine: CLASS 6.1: Poisonous material!!


Caffeine can lead to a condition known as ”caffeinism.” Caffeinism combines caffeine dependency with a wide range of unpleasant physical and mental conditions including nervousness, irritability, anxiety, tremulousness, muscle twitching (hyperreflexia), insomnia, headaches, respiratory alkalosis, and heart palpitations. Furthermore, because caffeine increases the production of stomach acid, high usage over time can lead to peptic ulcers, erosive esophagitis, and gastroesophageal reflux disease.

There are four caffeine-induced psychiatric disorders recognized by the ”Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition”: caffeine intoxication, caffeine-induced anxiety disorder, caffeine-induced sleep disorder, and caffeine-related disorder.

Long-term consumption of caffeine could inhibit learning and memory partially through inhibition of hippocampal neurogenesis.

Caffeine binds to receptors on the surface of heart muscle cells, which leads to an increase in the level of cAMP inside the cells (by blocking the enzyme that degrades cAMP), mimicking the effects of epinephrine (which binds to receptors on the cell that activate cAMP production).

Despite its widespread use and the conventional view that it is a safe substance, a 2008 study suggested that pregnant women who consume 200 milligrams or more of caffeine per day have about twice the miscarriage risk as women who consume none.


5-6 cups of coffee a day may make you fat!

Caffeine can cause retention of fat within cells, glucose intolerance(a pre-diabetic condition), and increase resistance to insulin regulation. 












High intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease. http://www.ncbi.nlm.nih.gov/pubmed/11237928



Personal note: I’ve been caffeine-free for about 8 months now. I’d given up caffeine a few years ago, but I went back to it after some stressful events. Caffeine just made me feel good/happy and I craved it when I felt bad or stressed.

The 1st time I gave it up was super-hard. I was consuming 8-16 cans of Coca-cola and energy drinks a day(insane, I know!). I switched that out to diet Coke and diet Pepsi, then I switched that out to strong tea. I gradually weakened the tea until I was just drinking water. I could not go cold-turkey because I have severe migraines. I had to slowly step it down.

This time, I went from energy drinks and soda straight to water. I had to use some Excedrin to get me through the 1st week. I naturally have 2-5 baaaaaad migraines every year (since I was about 2 years old). As long as I was consuming caffeine I wouldn’t have any, but if I was ever in a situation where I went without it for more than 6 hours – it would induce a monster migraine that would leave me crying in a fetal position. That could be several times a week. I much prefer to deal with my “regular” migraine episodes. I’ve only had 2 since I stopped consuming caffeine this last time. It’s also easier now for me to notice the signs of a migraine coming on – which means I have time to do a few things to take the edge off so that they don’t last as long and aren’t as severe.


Earlobe crease? Could be Cardio Vascular Disease or Metabolic Syndrome


Ear Lobe Crease (aka: ELC)

Linear wrinkles in one or both lobes may predict future cardiovascular events (heart attack, bypass surgery, or cardiac death.) A crease on one lobe raises the risk by 33%; a crease on both lobes increases it by 77%, even after adjusting for other known risk factors. Men with diagonal ear creases were 55 percent more likely to die of heart disease than men without ear creases. The risk was even greater for non-diabetic women.





Small yellow bumps under the skin around your eye? Could be heart trouble!

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People that have xanthelasmata(cholesterol deposits on the eyelids) are at significant increased risk of heart attacks, ischemic heart disease, and death. After reviewing almost 13,000 patient files, researchers found that when these yellowish lesions are observed, the risk of suffering a heart attack is increased 51%, the risk of suffering ischemic heart disease was increased 40%, and the risk of death was increased 17% — when compared with individuals who did not exhibit xanthelasmata. Around 50% of the patients had cholesterol that was within the normal range, but were still at increased risk of heart disease – due to the yellowish, flat lipid plaques on their eyelids.




Stopping & Preventing Seizures: Ketogenic Diet

“Research has shown that about one-third of children on the Ketogenic Diet become seizure-free, … and another one-third see a reduction in their seizures. Some children, after several years on the diet, are able to wean off both medication and the diet and go on to live a seizure-free life.”

Alzheimer’s patients on a ketogenic diet showed significant cognitive improvement compared to patients not following the diet. The diet may also help reduce oxidative stress and enhance mitochondrial function. Parkinson’s disease patients on the diet reduced their scores on the Unified Parkinson’s Disease Rating Scale by 43.4%. The diet may also prove helpful in the treatment of Amyotrophic Lateral Sclerosis, or ALS. Researchers speculate that the diet may prove helpful in even more neurological conditions, such as recovery from stroke and brain injury.

Doctors are using the Ketogenic Diet to prevent seizures in children: http://www.epilepsyfoundation.org/aboutepilepsy/treatment/ketogenicdiet/

Ketogenic Diet helps prevent seizures in 4 year old girl: http://www.gazettetimes.com/news/local/high-fat-ketogenic-diet-helps–year-old-keep-seizures/article_ca7dc366-6d66-541a-8516-4e87be41c9c0.html



Check out my other article: Starving Cancer: Ketogenic Diet



Say NO to SOY! Disruptive to female reproductive functions, lowers testosterone in males, effects unborn babies….


Soy, Isoflavones, Soybean, Tofu = Genistein Isoflavones, such as genistein and daidzein, are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee. Hundreds of studies say that more investigation is needed and cite numerous serious issues directly related to Soy/Genistein:

Gee JM and others. Increased induction of aberrant crypt foci(clusters of abnormal tube-like glands in the lining of the colon and rectum) by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya proteinCarcinogenesis 2000 Dec;21(12):2255-9. Genistein promotes induction of aberrant crypt foci by an as yet unidentified mechanism when fed immediately before treatment with 1,2-dimethylhydrazine.

Cassanova N and others. Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels. Endocrinology 2000 Oct;141(10):3898-907. Administration of genistein to rats significantly retarded most measures of pubertal spermatogenesis. Animals fed a soy-free diet had significantly larger testes than controls fed a soy-containing diet. “It is concluded that. . . the presence or absence of soy or genistein in the diet has significant short-term (pubertal spermatogenesis) and long-term (body weight, testis size, FSH levels and possibly mating) effects on males.”

Watanabe S and others. Effects of isoflavone supplement on healthy women. Biofactors 2000;12(1-4):233-41. After one month of taking 20 mg or 40 mg isoflavones daily, 60% of the young women had prolonged menstruation, 20% had shortened menstruation, 17% remained unchanged and 3% became irregular. Other hormonal changes “suggest that isoflavones influence not only estrogen receptor-related functions but the hypothalamo-hypophysis-gonadal axis(hypothalamus, pituitary gland, and gonad).”

Yang J and others. Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett 2000 Feb 28;149(1-2):171-9. “. . . perinatal genistein is an endocrine disrupter and increases the multiplicity of MNU-induced mammary carcinoma in rats.”

Salti GI and others. Genistein induces apoptosis(cell death) and topoisomerase II-mediated DNA breakage(DNA damage) in coloncancer cells. Eur J Cancer 2000 Apr;36(6):796-802. DNA breakage in colon cancer cells occurred within 1 hour of treatment with genistein.

Lephard ED and others. Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res 2000 Mar 17;859(1):123-31. Animals fed diets containing phytoestrogens for 5 weeks had elevated levels of phytoestrogens in the brain and a decrease of brain calcium-binding proteins. Calcium-binding proteins are associated with protection against neurodegenerative diseases.

Strick R and others. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemiaProc Natl Acad Sci USA 2000 Apr 25;97(9):4790-5. Researchers found that flavonoids, especially genistein, can cross the placenta and induce cell changes that lead to infant leukemia.

Chang HS and Doerge DR. Dietary genistein inactivates rat thyroid peroxidase(thyroid/iodine) in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 2000 Nov 1;168(3):244-52. The activity of thyroid peroxidase activity in soy-fed rats was reduced by up to 80% compared to those on a soy-free diet. As thyroid hormone levels and thyroid weights were no different between treated and untreated groups, the researchers concluded that “the remaining enzymatic activity is sufficient to maintain thyroid homeostasis in the absence of additional perturbations.” However, it is difficult or impossible to measure some of the more subtle manifestations of hypothyroidism in rats.

Gee JM and others. Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diet containing purified genistein or genistein-rich soya protein. Carcinogenesis 2000;21:2255-2259. Rats fed the isoflavone genistein exhibited pathological changes in the colon.

Ikeda T and others. Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia. Carcinogenesis 2000 Apr;21(4):707-13. Excess soybean intake with iodine deficiency caused abnormal growth of the thyroid gland.


Newbold RR and others. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 2001 Jun 1;61(11):4325-8. Genistein in soy was found to be more carcinogenic than DES, especially during “critical periods of differentiation.. . . the use of soy-based infant formulas in the absence of medical necessity and the marketing of soy products designed to appeal to children should be closely examined.”


de Lemos ML. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother 2001 Sep;35(9):118-21. “Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen. Women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products.”

Ju YH and others. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001 Nov;131(11):2957-62. Genistein stimulated breast tumor growth and cell proliferation in mice in a dose-responsive manner.


Nagao T and others. Reproductive effects in male and female rats of neonatal exposure to genistein. Reprod Toxicol 2001 Jul-Aug;15(4):399-411. Feeding of genistein to newborn rats resulted in lower body weight in male and female rats, estrous cycle irregularities and lowered fertility in female rats. Neonatal exposure to genistein caused dysfunction of postpubertal reproduction performance as well as abnormal development of gonads in female but not in male rats.


Allred CD and others. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 2001 Oct;22(10):1667-73. Genistin, the glycoside form of genistein, is converted to genistein by human saliva. The glycoside genistin, like the aglycone genistein, can stimulate estrogen-dependent breast cancer cell growth in vivo. Removal of genistin or genistein from the diet caused tumors to regress.


Whitehead SA and others. Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells. Hum Reprod 2002 Mar;17(3):589-94. Genistein directly inhibits steroid-production enzymes.


Klein SL and others. Early exposure to genistein exerts long-lasting effects on the endocrine and immune systems in rats. Mol Med 2002 Nov;8(11):742-9. Pregnant female rats were exposed to no, low (5 mg/kg diet) or high (300 mg/kg diet) genistein diets throughout gestation and lactation. At weaning, male offspring exposed to genistein perinatally were either switched to the genistein-free diet or remained on the genistein-dosed diets. At 70 days of age, immune organ masses, lymphocyte subpopulations, cytokine concentrations and testosterone concentrations were assessed in male offspring. Relative thymus masses were greater among males expose d to the high genistein diet than among males exposed to no genistein and certain markers of immune system function were also lower. Testosterone concentrations were lower among genistein-exposed than genistein-free males. These data illustrate that exposure to genistein during pregnancy and lactation exerts long-lasting effects on the endocrine and immune systems in adulthood. Whether exposure to phytoestrogens during early development affects responses to infectious or autoimmune diseases, as well ascancers, later in life requires investigation.


Doerge DR and DM Sheehan. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect 2002 Jun;110 suppl 3:349-53. “Soy is known to produce estrogenic isoflavones. Here, we briefly review the evidence for binding of isoflavones to the estrogen receptor, in vivo estrogenicity and developmental toxicity, and estrogen developmental carcinogenesis in rats. Genistein, the major soy isoflavone, also has a frank estrogenic effect in women. We then focus on evidence from animal and human studies suggesting a link between soy consumption and goiter, an activity independent of estrogenicity. Iodine deficiency greatly increases soy antithyroid effects, whereas iodine supplementation is protective. . . . Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both estrogenic and goitrogenic activities is of concern.”
Ju YH and others. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 2002 May 1;62(9):2474-7. Dietary genistein negated or overwhelmed the inhibitor effect of tamoxifen on tumor growth in ovariectomized and athymic mice. “Therefore, caution is warranted for postmenopausal women consuming dietary genistein while on TAM therapy for E-responsive breast cancer.”
Guo TL and others. Genistein modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats. Toxicol Appl Pharmacol 2002 Jun 15;181(3):219-27. Genistein caused a decrease in the percentage of helper T cells and an increase in the relative weights of spleen and thymus in rats.


Kumar NB and others. The specific role of isoflavones on estrogen metabolism in premenopausal women.Cancer 2002 Feb 15;94(4):1166-74. Sixty eight women consuming 40 mg soy isoflavones daily for 12 weeks had changes in steroid hormones and increased cycle length.


Chiang, CE and others. Genistein Inhibits the Inward Rectifying Potassium Current in Guinea Pig Ventricular Myocytes. J Biomed Sci 2002;9:321-326. Dietary isoflavones genistein dose-dependently and reversibly inhibit the inward rectifying K+ (potassium) current in guinea pigs ventricular myocytes, suggesting the potential for soy isoflavones to cause heart arrhythmias.


Lephard ED and others. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 2002 Jan-Feb;24(1):5-16. Male mice fed diets rich in phytoestrogens had lower levels of maze performance than male mice fed diets free of phytoestrogens. (Opposite results were observed in female mice.) The results indicate that consumption of dietary phytoestrogens resulting in very high plasma isoflavone levels (in many cases over a relatively short interval of consumption in adulthood) can significantly alter sexually dimorphic brain regions, anxiety, learning and memory.
Newbold R and others. Increased uterine cancer seen in mice injected with genistein, a soy estrogen, as newborns. Cancer Research 2002 Jun 1;61(11):4325-8. Infant mice given genistein developed cancer of the uterus later in life. “The data suggest that genistein is carcinogenic if exposure occurs during critical periods in a young animal’s development.


Tsutsui T and others. Cell-Transforming Activity And Mutagenicity of 5 Phytoestrogens In Cultured Mammalian Cells. Int J  Cancer 2003 105, 312-320. Phytoestrogens, such as Genistein and Dadzein, are responsible for the mutation of genes in mammals.

Unfer V and others. Endometrial effects of long-term treatment with phytoestrogens randomized, double blind, placebo-controlled study. Fertil Steril 2004 Jul;82(1):145-8. Women treated with soy phytoestrogens for 5 years were more likely to suffer from endometrial hyperplasia than those treated with a placebo.
Grace P and others. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancerand nutrition-norfolk. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):698-708. Women who had high concentration of Phystoestrogens were more likely to be at risk for breast cancer.

Chen AC and others. Genistein Inhibits Intestinal Cell Proliferation in Piglets. Pediatric Research 2005, Vol. 57, No. 2, 192-200. Three groups of piglets were fed either sow milk replacer, sow milk replacer with small amounts of genistein and soy milk replacer with large amounts of genistein. The study found that those piglets who had consumed the large and small amounts of genistein had suffered from “reduced enterocyte proliferation and migration.”
Note: Enterocytes are cells which make up most of the inner surface of the intestine.

Wood, C and others. Adrenocorticol Effects of Oral Estrogens and Soy Isoflavones in Female Monkeys. The Journal of Clinical Endocrinology and Metabolism 2005, Vol. 89 No. 5, 2319-2325. Three groups of female monkeys were fed either isoflavone depleted soy protein, soy protein with isoflavones or isoflavone depleted soy protein with conjugated equine estrogens, for 36 months. The group of monkeys fed the soy protein with isoflavones “had significantly lower adrenal weight… These findings suggest that long term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state.”

Doerge D and others. Lactational transfer of the soy isoflavone genistein, in Sprague-Dawley rats consuming dietary genistein. Reprod Toxicol 2006 Apr;21(3):307-12. The study shows that small amounts of genistein are present in the milk of mothers who consumed the substance.

Etcheverry P and others. Effect of Beef and Soy Proteins on the Absorption of Non-Heme Iron and Inorganic Zinc in Children. J Am Coll Nutr. 2006 Feb;25(1):34-40. Children who consumed beef meal had a “significantly greater” ability to absorb zinc and iron than those who consumed soy meal.
Glover A and others. Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression. Journal of Endocrinology (2006) 189, 565-573. “Adult males, fed a high phytoestrogen diet for 3 days, demonstrated significantly reduced fecundity… lipid peroxidation of epididymal sperm was significantly increased in animals fed a high phytoestrogen diet for 3 days. Disruption of the steroid regulation of the epididymis by phytoestrogens may alter its function, resulting in decreased quality of sperm, and thereby reducing fecundity.”
Milerova J and others. Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters. Clin Chem Lab Med 2006;44(2):171-4. Small differences in the amount of soy phytoestrogen consumed had moderately varying negative effects on the function of the thyroid gland.

Jefferson W and others. Disruption of the female reproductive system by the phytoestrogen genistein.Reproductive Toxicology (2007) 23( 3), 308-16. Different amounts of Genistein fed to rats had adverse effect on the ovaries and estrogen cycle. Twenty five milligrams per kilogram caused lessened fertility and complete infertility was seen at fifty milligrams per kilogram. The offspring of females who consumed twenty five milligrams per kilogram of genistein were shown to have a larger number of multi-oocyte follicles(cysts), than those whose mothers had not, showing us that the effects of genistein can be carried for multiple generations. “Thus neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood.”

Rachon D and others. Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 2007 Jun 20;57(2):161-70. “High dose consumption of commercially available preparations containing daidzein or puerarin may expose women with an intact uterus to the risk of endometrial hyperplasia.”
Goodin S and others. Clinical and biological activity of soy protein powder supplementation in healthy male volunteers. Cancer Epidemiol Biomarkers Prev 2007;16:829–33. Twelve men 18 years or older were fed 56 grams of pure soy per day for 28 days. Over the 28 days the men experienced a 19% drop in serum testosterone.

Chavarro J and others. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Human Reproduction 2008, Vol. 23. No. 10, 2584-90. Those men who consumed considerable amounts of soy food had lower sperm concentration. These findings stayed consistent with “age, abstinence time, body mass index, caffeine and alcohol intake and smoking.”

Eustache F and others. Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility. Environmental Health Perspec 2009 Aug;117(8):1272-9. “Chronic exposure to a mixture of a dose of phytoestrogen equivalent to that in the human diet and a low dose… of a common anti-androgenic food contaminant may seriously affect the male reproductive tract and fertility.”

Jefferson W and others. Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system. Environmental Health Perspective 2009 Dec;117(12):1883-9. When female newborns are exposed genistin, (the glycosylated form of genistein), it can cause harm to the reproductive system. This harm took the form of “delayed vaginal opening… abnormal estrous cycles, decreased fertility, and delayed parturition.”
Pastuszewska B and others. Nutritional value and physiological effects of soya-free diets fed to rats during growth and reproduction. J Anim Physiol Anim Nutr (Berl). 2008 Feb;92(1):63-74. The groups of rats fed egg and milk protein, instead of soy, showed superior reproductive performance.

Sosic-Jurjevic, B and others. Suppressive effects of genistein and daidzein on pituitary-thyroid axis in orchidectomized middle-aged rats. Experimental Biology and Medicine 2010 May;235(5):590-8. Two groups of middle-aged rats were fed 10 milligrams per kilo of either Dazein or Genistein for three weeks and a third group was fed regular feed. “This study provides…direct evidence that (Genistein and Dadzein) can induce microfollicular changes in the thyroid tissue and reduce the level of thyroid hormones…”

Yu C and others. Maternal exposure to daidzain alters behavior and oestrogen receptor alpha expression in adult female offspring. Behavioral Pharmacology May 2010. “Maternal exposure to daidzein has a masculinisation effect on memory and social behavior.”

Ward H and others. Breast, colorectal, and prostate cancer risk in the European Prospective Investigation intoCancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition 2010 Feb;91(2):440-8. “Dietary phytoestrogens may contribute to the risk of colorectal cancer among women and prostate cancer among men.”

Cimafranca M and others. Acute and chronic effects of oral genistein administration in neonatal mice. Biology of Reproduction 2010 Jul;83(1):114-21. This study was conducted in order “to develop a mouse model that more closely mimics the oral genistein exposure and total serum genistein concentrations observed in soy formula-fed infants.” Baby mice were fed soy formula until the fifth day after birth. The results showed that the “genistein treatment caused increased relative uterine weight and down-regulation of progesterone receptor in uterine epithelia. Estrogenic effects of genistein were also seen in the neonatal ovary and thymus, which had an increase in the incidence of multioocyte follicles (cysts) and a decrease in thymic weight relative to body weight, respectively. The increased incidence of MOFs persisted into adulthood for neonatally treated genistein females, and estrous cycle abnormalities were seen at 6 mo of age.”

Cedarroth C and others. Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.Molecular and Cellular Endocrinology 2010 Jun 10;321(2):152-60. Two groups of male mice were fed diets either containing large amounts of soy or no soy at all. The results showed “that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a small decrease in sperm count and fertility.”

Balkrishnan B and others. Transplacental Transfer and Biotransformation of Genistein in the human placenta.Placenta 2010 June;31(6):506-511. Genistein has the ability to come through the placenta of healthy human fetuses.

Click here to read the entire article with studies dating back to th 1950’s

Sensitive to sugar, diabetic, or just cutting it out of your diet? Glycemic Index & Load Chart (White Rice is worse than a can of Cola!!!)

The glycemic index (GI) is a ranking of carbohydrates on a scale from 0 to 100 according to the extent to which they raise blood sugar levels after eating. Foods with a high GI are those which are rapidly digested and absorbed and result in marked fluctuations in blood sugar levels. Low-GI foods, by virtue of their slow digestion and absorption, produce gradual rises in blood sugar and insulin levels, and have proven benefits for health. Low GI diets have been shown to improve both glucose and lipid levels in people with diabetes (type 1 and type 2). They have benefits for weight control because they help control appetite and delay hunger. Low GI diets also reduce insulin levels and insulin resistance.

The glycemic load of a food tells how much eating that food raises blood glucose. It is a similar concept as the glycemic index, except it takes serving sizes into account. The formula is to take the number of grams of carbohydrate in the serving, multiply by the glycemic index, and divide by 100. Theoretically, if a food has glycemic load of one point, it would raise the blood sugar as much as one gram of glucose.

An awareness of foods’ Glycemic Index can help you control your blood sugar levels, and by doing so, may help you prevent heart disease, improve cholesterol levels, prevent insulin resistance and type-2 diabetes, prevent certain cancers, and achieve or maintain a healthy weight. A substantial amount of research suggests a low GI diet provides these significant health benefits.

After we eat carbohydrate-rich foods, our digestive process breaks them down and turns them into glucose, which enters bloodstream. (Since most proteins and fats are not turned into glucose , they have much less of an immediate effect on our blood sugar). Glucose in the bloodstream triggers the production of insulin, a hormone that helps glucose get into cells where it can be used for energy. Once our immediate energy needs have been met, extra glucose still remaining in the bloodstream will be stored in our muscles and liver for later use. If our muscle and liver stores of glucose are full, but we still have extra glucose floating around in our blood, then our body will store this excess sugar as fat.

Food Glycemic Index One Serving Glycemic Load
Coca-Cola 63 250ml 16
Gatoraide 78 250ml 12
Instant Oatmeal 83 250ml 30
Cornflakes 93 250ml 23
Quinoa 53 150ml 13
White Rice 89 150ml 43
Brown Rice 50 150ml 16
Apple 39 120ml 6
Banana 62 120ml 16
Grapefruit 25 120ml 3
Orange 40 120ml 4
Pear 38 120ml 4
Prune 29 60ml 10
Raisins 64 60ml 28
Watermelon 72 120ml 4
Peanuts 7 50ml 0
Black Beans 30 150ml 7
Carrots 35 80ml 2
Boiled White Potato(average) 82 150ml 21
Sweet Potato 70 150ml 22
Bread – French baguette 95 1oz.
Cereal Cheerios General Mills 95 1 cup, 1oz.
Cereal Rice Chex General Mills 89 1 1/4 cup, 1oz.
Cherries 22 10 large, 3oz.
Dark Chocolate(60%+ cocoa) 22
Crackers – saltine 72
Tofu frozen dessert low fat 115  1/2 cup, 2 ozs
Dates, dried 103  5 or 1.4ozs
Parsnips, boiled 97  1/2 cup, 2.5 ozs.
Sweet potato, peeled, boiled 54 1/2 cup mashed, 3 ozs.
White bread 70 1 slice or 1oz
Whole wheat bread 69 1 slice or 1oz
French fries 75
Grapenuts Cereal 75  30g  16
Pineapple, raw 66  120g  6
Ocean Spray Cranberry juice cocktail 68  250ml  24
Beef steak, battered, fried, lean & fat eaten 50  250ml  3.6

A food is generally considered to have a high GI if it is rated above 60.

Individuals who have problems with maintaining proper blood sugar levels should restrict their selection to foods with a GI of 40 or less. These include those who have low blood sugar (hypoglycemia) and high blood sugar (hyperinsulemia) as well as those who have a high sensitivity to sugar. Sugar includes not just simple sugars, honey and maple syrup but also fruits, fruit juices, starchy vegetables and grain products or foods with a high glycemic index.

FYI…..Average GI of beer = 110.

Why doesn’t the GI chart include things like beef, chicken, fish, nuts, seeds, avocadoes, and berries? These foods contain no carbohydrate, or so little that their GI cannot be tested according to the standard methodology. Bear in mind that the GI is a measure of carbohydrate quality. Essentially, these types of foods, eaten alone, won’t have much effect on your blood glucose levels.

Beach Almond – use it for: liver diseases, dermatitis, dysentery, diarrhea & cancer

Terminalia_catappa 2

Beach almond, or Terminalia catappa, is a tropical deciduous tree that produces an almond-like edible nut. Traditional healers use the leaves to treat hepatitis and other liver diseases, dermatitis, dysentery, diarrhea and cancer. Active ingredients include flavonoids, tannins, saponins and sterols, and the plant has antioxidant, anti-inflammatory and liver-protective properties. A study by S. Kinoshita and colleagues published in the November 2007 issue of “Phytomedicine” tested a leaf extract on animals with induced liver damage. The study found that the tannin known as corilagin scavenged free radicals and reduced oxidative damage in the liver, thereby repairing and protecting liver tissue. This study supports the traditional use of the plant in treating liver diseases and its ability to repair liver damage. Consult a health care professional before using this herb, since the long-term effects are not known. Do not use during pregnancy or breastfeeding.

Good night’s sleep linked to happiness

sleep-image-001“The team found that, as expected, having a more positive general outlook on life was associated with improved sleep quality. However, they found that the more reactive or fragile a participant’s positive emotions were in relation to external events, the more their sleep was impaired, especially for individuals high in positivity to begin with.”  Read more