Sweet Apple Smoothie for digestive health maintenance…

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The last smoothie I made (using greens) didn’t go well, but this one tastes great! For anyone looking to add more probioitics into their diet, natural yogurt can be helpful. The yogurt that most people buy from a grocery store is full of harmful ingredients such as high fructose corn syrup, artificial dyes and flavoring, etc. Kellogg’s yogurt contains BHT & High Fructose Corn Syrup, Chobani contains added flavors and concentrates, many of Dannon’s yogurts contain artificial flavors, potassium sorbate, & other harmful additives.

I personally cannot stand the flavor of natural yogurt – it’s too sour/bitter/blah for me…so I prefer to mix it in with other foods like a meat dish, or in this case – a smoothie. Do NOT cook the yogurt – it will kill the good probiotics – add it in afterward. The ingredients I used:

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  1. 1/2 cup prune juice (just natural pune juice, no concentrate, no added sugar, etc)
  2. 1 banana
  3. 1 medium apple
  4. 1/4 cup yogurt (use the most natural/organic yogurt you can get)
  5. 1 serving cup of natural, unsweetened/unflavored applesauce
  6. 1/4 cup of coconut water
  7. 3-5 ice cubes

Put all ingredients into a blender and blend until smooth. This recipe almost filled 2 red solo cups – makes plenty for you to have one now and put the other one in the fridge for later or share with a friend. You could easily add other ingredients such as ginger, coconut, parsley, cinnamon, etc.

Specific brands I used:

Yogurt: White Mountain Bulgarian Yogurt (I think it’s made in Austin, I bought it at HEB – it’s the best I can find near me)

Coconut juice: VitaCoco 100% Pure Coconut Water

Unsweetened applesauce: HEB Unsweetened Applesauce 6pk

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Top Cancer Killers

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Loma Linda University  reported that people who ate beans at least three times a week had a 33% reduced risk of colon polyps (which often lead to colon cancer).

Researchers at Colorado State University reported on the anticancer abilities of beans: white kidney beans have greater impact on cancer cells than navy beans, and that more colorful beans have milder effects. Foods that were found to be especially protective against head and neck cancers, which include cancer of the mouth, throat, and larynxthese cancers included beans, carrots, and tomatoes, among others.

1305104161078Broccoli and other cruciferous vegetables, such as cabbage, cauliflower, brussel sprouts, and kale, among others, contain several compounds shown to fight cancer.

Carrots are an excellent source of beta-carotene, a potent antioxidant that has been associated with a reduced risk of various cancers, including prostate, mouth, throat, colon, stomach, and bladder. This does not include beta-carotene supplements – to receive the benefits, carrots must be eaten.

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In one laboratory study, capsaicin slowed the growth of prostate cancer cells and prompted apoptosis (cell suicide), while a subsequent study found similar results regarding apoptosis and prostate cancer cells. Capsaicin also fights stomach cancer.

Garlic contains allium compounds that enhance the activity of immune system cells designed to fight cancer – they block carcinogens from getting into cells and also slow the development of tumors.

Mushrooms, including shiitake, reishi, coriolus versicolor, and maitake, have demonstrated cancer-fighting properties. The anticancer abilities are attributed to polysaccharides, including beta glucan, which enhance the immune system and strengthen it against cancer. Mushrooms also contain complex protein/sugar molecules called lectin, which have an ability to prevent cancer cells from multiplying. Another compound in mushrooms is ergosterol peroxide, which can inhibit the growth or prostate cancer cells and prompt apoptosis, according to a study reported in Chemico Biological Interactions. The yamabushitake mushroom has demonstrated potential against human leukemia.

Raspberries have been shown to decrease the number of esophageal tumors. In subsequent studies, black raspberry extracts inhibited the growth of colon cancer cells.

A recent review in Current Medicinal Chemistry reports on the impact of lycopene on cancer in general, and how its potent antioxidant properties help it prevent cell damage and inhibit cell growth. In addition, some case-control studies have shown that greater consumption of tomatoes and lycopene is associated with a reduced risk of lung cancer.

The spice turmeric: Curcumin, the active ingredient in turmeric, appears to involve a blend of anti-carcinogenic, pro-apoptotic, anti-angiogenic, anti-metastatic, immunomodulatory and antioxidant activities. One study showed  it inhibited the growth of both human and animal prostate cancer cell lines.

450lb Man lost 250lbs on Dollar Store Diet

 

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At one point in his life, Joe had been laid off from his job and wanted to make some changes. He couldn’t afford a gym membership or fancy diet. So he did the one workout that he could afford and physically manage… walking. He lost over 200 pounds by walking and eating discounted healthy food. He walked five miles a day, every day, rain or shine. He went through his fridge with a trash bag, replacing the soda with water and stocking up on fruits, veggies, nuts and high-protein meats like tuna, chicken, and lean beef. He says, “Not only was I giving myself the gift of better health – I was saving money in the process!”

Articles: http://health.yahoo.net/experts/yourbestfitness/99-cent-diet-could-it-work-you

His websites:

http://www.joejoenow.com/

http://www.joewalking.com

See Joe’s episode on The Doctors (thedoctorstv.com – I personally LOVE watching this show!!): http://www.youtube.com/watch?feature=player_embedded&v=JbJRdd3v074

Why you should avoid Caffeine – it can make you fat, alter your DNA, and it’s toxic.

caffeine_drinks  eu_toxic_chemicals_222   coffee    toxc2

The LD50 (Lethal Dose 50%) of  caffeine is 192 mg. The lower the LD50 number, the more lethal the substance is. For comparison, Vitamin C (ascorbic acid) has an LD50 of 11,900 mg/kg. Cyanide has an LD50 of 6.4 mg/kg.

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Caffeine is mutagenic for mammalian somatic cells (meaning that is alters your DNA and is passed down genetically to offspring). Mutagenic for bacteria and/or yeast. May cause damage to the following organs: heart, gastrointestinal tract, central nervous system.

It has Chronic Effects on Humans: May cause adverse reproductive effects (fetotoxicity, maternal (parnutrition) and birth defects. May affect genetic material (mutagenic). May cause cancer (tumorgenic) based on animal data.

It may cause gastrointestinal (digestive) tract irritation with epigastric pain, abdominal cramps, nausea, vomiting and diarrhea.

It affects metabolism and cardiovascular system with symptoms including flushing, palpitations, rapid heart rate, dysrhythmias, hypotension, blood pressure elevation and weight loss, metabolic acidosis.

It may affect brain and behavior/central nervous system. Symptoms may include nervousness, anxiety, restlessness, insomnia, dizziness, tremor, seizures, convulsions, hallucinations,
somnolence, toxic psychosis, tremors, convulsions, ataxia.

May also affect blood, respiration (hyperventilation), and urinary system (mild increase in urinary volume and urinary sodium excretion), and may directly produce hypokalemia.

Chronic Potential Health Effects: May cause cancer (tumorigen) based on animal studies. May cause reproductive and fetal effects. May cause digestive tract disturbances (increased gastric acid, and pepsin secretion and a decrease in lower esophogeal sphincter pressure), cardiovascular disturbances.

Caffeine also fits the definition of an addictive substance, with withdrawal symptoms, an increase in tolerance over time, and physical cravings.

Caffeine is metabolized in the liver.

It increases lipolysis, leading to elevated glycerol and free fatty acid levels in the blood plasma.

It dilates blood vessels and increases urine volume.

Caffeine crosses the blood–brain barrier that separates the bloodstream from the interior of the brain.

Caffeine acts as a nonselective antagonist of adenosine receptors. The caffeine molecule is structurally similar to adenosine, and binds to adenosine receptors on the surface of cells without activating them (an “antagonist” mechanism of action). Therefore, caffeine acts as a competitive inhibitor.

Caffeine tolerance develops very quickly, especially among heavy coffee and energy drink consumers. Complete tolerance to sleep disruption effects of caffeine develops after consuming 400 mg of caffeine 3 times a day for 7 days. Full complete tolerance of caffeine was observed when subjects consumed 750–1200 mg per day.

Withdrawal symptoms — headache, irritability, an inability to concentrate, drowsiness, insomnia and pain in the stomach, upper body, and joints — may appear within 12 to 24 hours after discontinuation of caffeine intake. This peaks at roughly 48 hours, and usually last from one to five days, representing the time required for the number of adenosine receptors in the brain to revert to “normal” levels. Analgesics, such as aspirin, can relieve the pain symptoms.

The DOT Classification of caffeine: CLASS 6.1: Poisonous material!!

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Caffeine can lead to a condition known as ”caffeinism.” Caffeinism combines caffeine dependency with a wide range of unpleasant physical and mental conditions including nervousness, irritability, anxiety, tremulousness, muscle twitching (hyperreflexia), insomnia, headaches, respiratory alkalosis, and heart palpitations. Furthermore, because caffeine increases the production of stomach acid, high usage over time can lead to peptic ulcers, erosive esophagitis, and gastroesophageal reflux disease.

There are four caffeine-induced psychiatric disorders recognized by the ”Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition”: caffeine intoxication, caffeine-induced anxiety disorder, caffeine-induced sleep disorder, and caffeine-related disorder.

Long-term consumption of caffeine could inhibit learning and memory partially through inhibition of hippocampal neurogenesis.

Caffeine binds to receptors on the surface of heart muscle cells, which leads to an increase in the level of cAMP inside the cells (by blocking the enzyme that degrades cAMP), mimicking the effects of epinephrine (which binds to receptors on the cell that activate cAMP production).

Despite its widespread use and the conventional view that it is a safe substance, a 2008 study suggested that pregnant women who consume 200 milligrams or more of caffeine per day have about twice the miscarriage risk as women who consume none.

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5-6 cups of coffee a day may make you fat!

Caffeine can cause retention of fat within cells, glucose intolerance(a pre-diabetic condition), and increase resistance to insulin regulation. 

http://www.dailymail.co.uk/health/article-2332044/Is-caffeine-fix-making-fat-Study-shows-cups-coffee-day-cause-obesity.html?ito=feeds-newsxml

LD50 LETHAL DOSE CHART:

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drinks

http://www.sciencelab.com/msds.php?msdsId=9927475

http://www.sciencelab.com/msdsList.php

http://www.epa.gov/agriculture/ag101/pestlethal.html

https://en.wikipedia.org/wiki/Median_lethal_dose#cite_note-21

http://www.ingredientstodiefor.com/files/MSDS_Caffeine.pdf

http://en.wikipedia.org/wiki/HAZMAT_Class_6_Toxic_and_Infectious_Substances

http://www.fda.gov/downloads/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingOver-the-CounterMedicines/UCM205286.pdf

High intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease. http://www.ncbi.nlm.nih.gov/pubmed/11237928

http://www.news-medical.net/health/Caffeine-Pharmacology.aspx

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Personal note: I’ve been caffeine-free for about 8 months now. I’d given up caffeine a few years ago, but I went back to it after some stressful events. Caffeine just made me feel good/happy and I craved it when I felt bad or stressed.

The 1st time I gave it up was super-hard. I was consuming 8-16 cans of Coca-cola and energy drinks a day(insane, I know!). I switched that out to diet Coke and diet Pepsi, then I switched that out to strong tea. I gradually weakened the tea until I was just drinking water. I could not go cold-turkey because I have severe migraines. I had to slowly step it down.

This time, I went from energy drinks and soda straight to water. I had to use some Excedrin to get me through the 1st week. I naturally have 2-5 baaaaaad migraines every year (since I was about 2 years old). As long as I was consuming caffeine I wouldn’t have any, but if I was ever in a situation where I went without it for more than 6 hours – it would induce a monster migraine that would leave me crying in a fetal position. That could be several times a week. I much prefer to deal with my “regular” migraine episodes. I’ve only had 2 since I stopped consuming caffeine this last time. It’s also easier now for me to notice the signs of a migraine coming on – which means I have time to do a few things to take the edge off so that they don’t last as long and aren’t as severe.

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Coconut Facts

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It has been used for thousands of years in ancient India as a healing fruit.

It takes around 9 months for a coconut to filter all of the water that it contains. This makes the water completely pure & sterile, which is why it can be used for blood transfusions.

It has the highest concentration of electrolytes of anything found in nature.

Younger coconuts contain the purest unsaturated fats and are better than mature coconuts.

It boots the immune system, boosts metabolism, and improves thyroud function.

It makes a great topical oil(use a TINY bit – it goes a long way!) that can help to naturally rid the skin of dangerous toxins. It also gives the skin the perfect mix of hydration and antioxidants that it needs to stay healthy, smooth and younger-looking longer.

Eight ounces of coconut water has 46 calories, 9 grams of carbohydrates, 250 mg of sodium, 200-500 mg of potassium, 60 mg of magnesium, 45 mg of phosphorus, and 2 grams of protein. The electrolyte content is more than double that of traditional sports drinks with about half of the carbohydrates. (Potassium is an essential macromineral in human nutrition; it is the major cation (positive ion) inside cells, and it is important in maintaining fluid and electrolyte balance in the body.)

According to researchers, individuals with high blood pressure usually have low potassium levels. Therefore, drinking coconut water on a regular basis can be quite effective at regulating blood pressure.

Coconut milk (made from the meat of the coconut) has 500-600 calories, and coconut water(liquid inside) contains about 50 calories.

A few studies have shown coconut water to have cytokinins which are beneficial for anti-aging, anti-carcinogenic and anti-thrombotic effects. The American Institute for Cancer Research says that some of the compounds in coconut water, such as selenium, have antioxidant properties and fight cancer in the lab(many common fruits and vegetables are packed with these compounds). Several animal studies suggest coconut water can lower cholesterol and blood pressure, but this research is too preliminary to make any claims  yet.

An article with numerous facts & info: http://www.organicfacts.net/organic-oils/organic-coconut-oil/health-benefits-of-coconut-oil.html

Another article with information & factoids: http://www.thepaleosecret.com/2012/07/19/top-10-health-benefits-of-coconut-oil/
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Infographic-Benefits-of-Coconut-Oil

Remedy for gray hair & baldness

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Onion juice

Research has found that grey hair is primarily caused by a buildup of hydrogen peroxide at the root of hair follicles and that this is due in great part to a reduction in the natural antioxidant compound catalase. In addition to helping cleanse the scalp and follicles, onion juice also promotes the production of catalase. Catalase prevents grey hair as well as promotes thicker hair follicles. It is also shown to work for the skin condition vitiligo.

How-to: Divide your hair into four sections, then apply the onion juice on your scalp not on your hair. Massage gently and leave it on for 15 minutes till 1 hour, then rinse you hair well. Apply it daily and after 2 weeks ( at least) you may see great results. Shampoo afterwards to help remove the onion odor.

Some helpful links with more information on gray hair & baldness remedies:

http://food.ndtv.com/beauty/onions-for-hair-fall-an-inexpensive-way-to-promote-hair-growth-1271456

http://www.naturalnews.com/040262_thinning_hair_grey_onion_juice.html

http://www.onlymyhealth.com/onion-juice-hair-loss-1359096093

http://www.americanathleticinstitute.org/natural-home-remedies/101-tips-on-how-to-make-your-hair-grow-quicker.php

Foods that fight cancer

Garlic

Garlic – Garlic belongs to the family of vegetables called Allium, which includes onions, scallions, leeks and chives. Laboratory research has shown that one garlic component, called diallyl disulfide, exerts potent preventive effects against cancers of the skin, colon and lung. Recently, this compound proved able to kill leukemia cells in the laboratory. A compound derived from garlic called ajoene has displayed similar activity. Garlic protects against stomach cancer and decreases one’s chances of developing colorectal cancer. The higher the exposure to the food = the greatest decrease in risk. In laboratory studies, components of garlic have shown the ability to slow or stop the growth of tumors in prostate, bladder, colon and stomach tissue.

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Peanuts, Grapes, & Mulberry Fruit – They all contain resveratrol, a type of natural phytochemical that belongs to a much larger group of phytochemicals called polyphenols. Laboratory research points to resveratrol’s ability to slow the growth of cancer cells and inhibit the formation of tumors in lymph, liver, stomach and breast cells. Resveratrol has also triggered the death of leukemic and colon cancer tumors. In one series of studies, resveratrol blocked the development of skin, breast and leukemia cancers at all three stages of the disease (initiation, promotion and progression).

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Tomatoes  – Their red hue comes chiefly from a phytochemical called lycopene. Reasearch has  found substantial and convincing evidence that foods containing lycopene probably protect against prostate cancer. Consumption of tomato compounds has been linked to large decreases in prostate cancer risk. Moreover, there is evidence that this cancer-fighting potential is increased if tomatoes are consumed in a processed form that allows these natural compounds to be released and more easily absorbed, such as tomato sauce, tomato paste or tomato juice. In the laboratory, tomato components have stopped the proliferation of several other cancer cells types, including breast, lung, and endometrial.

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Ginger – Ginger causes cancer cell apoptosis(apoptosis is when cancer cells “commit suicide”). The anti-inflammatory properties of ginger prevent precancerous tumors from creating the perfect breeding ground and climate for growth. Ginger also causes autophagy, meaning that ginger tricks the cancerous cells into eating themselves. Researchers have found that ginger exhibited a highly prized anti-cancer trait known as selective cytotoxicity: it inhibited the reproduction of cancer cells while leaving healthy cells largely unaffected. No conventional cancer treatment on the market exhibits this property.

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Citrus Fruits – Citric acid and flavonoids in citrus fruits contributes to their antioxidant & anti-cancer properties. Citrus fruit consumption increases your protection from oral cancer,  and cancers of the digestive and upper respiratory tract. A 2010 study showed that citric acid alone does not protect against cancer – it works best when the fruit is consumed because the flavonoid/citric acid combination is what works and protects against cancers. Limes & lemons have the highest concentration of citric acid – as much as 8% of their dry weight. Citrus foods: limes, lemons, grapefruit, oranges, berries, pineapples, tamarind, tomatoes, & cherries. Please note: If you are taking medication, please consult your doctor before increasing your citric acid consumption – it can interfere with absorption and effectiveness. Also, consuming too much citric acid can have some side effects such as PH balance disturbance, diarrhea, nausea, etc.

 

 

 

 

Say NO to SOY! Disruptive to female reproductive functions, lowers testosterone in males, effects unborn babies….

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Soy, Isoflavones, Soybean, Tofu = Genistein Isoflavones, such as genistein and daidzein, are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee. Hundreds of studies say that more investigation is needed and cite numerous serious issues directly related to Soy/Genistein:

2000
Gee JM and others. Increased induction of aberrant crypt foci(clusters of abnormal tube-like glands in the lining of the colon and rectum) by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya proteinCarcinogenesis 2000 Dec;21(12):2255-9. Genistein promotes induction of aberrant crypt foci by an as yet unidentified mechanism when fed immediately before treatment with 1,2-dimethylhydrazine.

2000
Cassanova N and others. Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels. Endocrinology 2000 Oct;141(10):3898-907. Administration of genistein to rats significantly retarded most measures of pubertal spermatogenesis. Animals fed a soy-free diet had significantly larger testes than controls fed a soy-containing diet. “It is concluded that. . . the presence or absence of soy or genistein in the diet has significant short-term (pubertal spermatogenesis) and long-term (body weight, testis size, FSH levels and possibly mating) effects on males.”

2000
Watanabe S and others. Effects of isoflavone supplement on healthy women. Biofactors 2000;12(1-4):233-41. After one month of taking 20 mg or 40 mg isoflavones daily, 60% of the young women had prolonged menstruation, 20% had shortened menstruation, 17% remained unchanged and 3% became irregular. Other hormonal changes “suggest that isoflavones influence not only estrogen receptor-related functions but the hypothalamo-hypophysis-gonadal axis(hypothalamus, pituitary gland, and gonad).”

2000
Yang J and others. Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett 2000 Feb 28;149(1-2):171-9. “. . . perinatal genistein is an endocrine disrupter and increases the multiplicity of MNU-induced mammary carcinoma in rats.”

2000
Salti GI and others. Genistein induces apoptosis(cell death) and topoisomerase II-mediated DNA breakage(DNA damage) in coloncancer cells. Eur J Cancer 2000 Apr;36(6):796-802. DNA breakage in colon cancer cells occurred within 1 hour of treatment with genistein.

2000
Lephard ED and others. Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res 2000 Mar 17;859(1):123-31. Animals fed diets containing phytoestrogens for 5 weeks had elevated levels of phytoestrogens in the brain and a decrease of brain calcium-binding proteins. Calcium-binding proteins are associated with protection against neurodegenerative diseases.

2000
Strick R and others. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemiaProc Natl Acad Sci USA 2000 Apr 25;97(9):4790-5. Researchers found that flavonoids, especially genistein, can cross the placenta and induce cell changes that lead to infant leukemia.

2000
Chang HS and Doerge DR. Dietary genistein inactivates rat thyroid peroxidase(thyroid/iodine) in vivo without an apparent hypothyroid effect. Toxicol Appl Pharmacol 2000 Nov 1;168(3):244-52. The activity of thyroid peroxidase activity in soy-fed rats was reduced by up to 80% compared to those on a soy-free diet. As thyroid hormone levels and thyroid weights were no different between treated and untreated groups, the researchers concluded that “the remaining enzymatic activity is sufficient to maintain thyroid homeostasis in the absence of additional perturbations.” However, it is difficult or impossible to measure some of the more subtle manifestations of hypothyroidism in rats.

2000
Gee JM and others. Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diet containing purified genistein or genistein-rich soya protein. Carcinogenesis 2000;21:2255-2259. Rats fed the isoflavone genistein exhibited pathological changes in the colon.

2000
Ikeda T and others. Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia. Carcinogenesis 2000 Apr;21(4):707-13. Excess soybean intake with iodine deficiency caused abnormal growth of the thyroid gland.

2001

Newbold RR and others. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 2001 Jun 1;61(11):4325-8. Genistein in soy was found to be more carcinogenic than DES, especially during “critical periods of differentiation.. . . the use of soy-based infant formulas in the absence of medical necessity and the marketing of soy products designed to appeal to children should be closely examined.”

2001

de Lemos ML. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother 2001 Sep;35(9):118-21. “Genistein and daidzein may stimulate existing breast tumor growth and antagonize the effects of tamoxifen. Women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products.”

2001
Ju YH and others. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001 Nov;131(11):2957-62. Genistein stimulated breast tumor growth and cell proliferation in mice in a dose-responsive manner.

2001

Nagao T and others. Reproductive effects in male and female rats of neonatal exposure to genistein. Reprod Toxicol 2001 Jul-Aug;15(4):399-411. Feeding of genistein to newborn rats resulted in lower body weight in male and female rats, estrous cycle irregularities and lowered fertility in female rats. Neonatal exposure to genistein caused dysfunction of postpubertal reproduction performance as well as abnormal development of gonads in female but not in male rats.

2001

Allred CD and others. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 2001 Oct;22(10):1667-73. Genistin, the glycoside form of genistein, is converted to genistein by human saliva. The glycoside genistin, like the aglycone genistein, can stimulate estrogen-dependent breast cancer cell growth in vivo. Removal of genistin or genistein from the diet caused tumors to regress.

2002

Whitehead SA and others. Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells. Hum Reprod 2002 Mar;17(3):589-94. Genistein directly inhibits steroid-production enzymes.

2002

Klein SL and others. Early exposure to genistein exerts long-lasting effects on the endocrine and immune systems in rats. Mol Med 2002 Nov;8(11):742-9. Pregnant female rats were exposed to no, low (5 mg/kg diet) or high (300 mg/kg diet) genistein diets throughout gestation and lactation. At weaning, male offspring exposed to genistein perinatally were either switched to the genistein-free diet or remained on the genistein-dosed diets. At 70 days of age, immune organ masses, lymphocyte subpopulations, cytokine concentrations and testosterone concentrations were assessed in male offspring. Relative thymus masses were greater among males expose d to the high genistein diet than among males exposed to no genistein and certain markers of immune system function were also lower. Testosterone concentrations were lower among genistein-exposed than genistein-free males. These data illustrate that exposure to genistein during pregnancy and lactation exerts long-lasting effects on the endocrine and immune systems in adulthood. Whether exposure to phytoestrogens during early development affects responses to infectious or autoimmune diseases, as well ascancers, later in life requires investigation.

2002

Doerge DR and DM Sheehan. Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect 2002 Jun;110 suppl 3:349-53. “Soy is known to produce estrogenic isoflavones. Here, we briefly review the evidence for binding of isoflavones to the estrogen receptor, in vivo estrogenicity and developmental toxicity, and estrogen developmental carcinogenesis in rats. Genistein, the major soy isoflavone, also has a frank estrogenic effect in women. We then focus on evidence from animal and human studies suggesting a link between soy consumption and goiter, an activity independent of estrogenicity. Iodine deficiency greatly increases soy antithyroid effects, whereas iodine supplementation is protective. . . . Although safety testing of natural products, including soy products, is not required, the possibility that widely consumed soy products may cause harm in the human population via either or both estrogenic and goitrogenic activities is of concern.”
2002
Ju YH and others. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 2002 May 1;62(9):2474-7. Dietary genistein negated or overwhelmed the inhibitor effect of tamoxifen on tumor growth in ovariectomized and athymic mice. “Therefore, caution is warranted for postmenopausal women consuming dietary genistein while on TAM therapy for E-responsive breast cancer.”
2002
Guo TL and others. Genistein modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F(0) and F(1) generations of Sprague-Dawley rats. Toxicol Appl Pharmacol 2002 Jun 15;181(3):219-27. Genistein caused a decrease in the percentage of helper T cells and an increase in the relative weights of spleen and thymus in rats.

2002

Kumar NB and others. The specific role of isoflavones on estrogen metabolism in premenopausal women.Cancer 2002 Feb 15;94(4):1166-74. Sixty eight women consuming 40 mg soy isoflavones daily for 12 weeks had changes in steroid hormones and increased cycle length.

2002

Chiang, CE and others. Genistein Inhibits the Inward Rectifying Potassium Current in Guinea Pig Ventricular Myocytes. J Biomed Sci 2002;9:321-326. Dietary isoflavones genistein dose-dependently and reversibly inhibit the inward rectifying K+ (potassium) current in guinea pigs ventricular myocytes, suggesting the potential for soy isoflavones to cause heart arrhythmias.

2002

Lephard ED and others. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 2002 Jan-Feb;24(1):5-16. Male mice fed diets rich in phytoestrogens had lower levels of maze performance than male mice fed diets free of phytoestrogens. (Opposite results were observed in female mice.) The results indicate that consumption of dietary phytoestrogens resulting in very high plasma isoflavone levels (in many cases over a relatively short interval of consumption in adulthood) can significantly alter sexually dimorphic brain regions, anxiety, learning and memory.
2002
Newbold R and others. Increased uterine cancer seen in mice injected with genistein, a soy estrogen, as newborns. Cancer Research 2002 Jun 1;61(11):4325-8. Infant mice given genistein developed cancer of the uterus later in life. “The data suggest that genistein is carcinogenic if exposure occurs during critical periods in a young animal’s development.

2003

Tsutsui T and others. Cell-Transforming Activity And Mutagenicity of 5 Phytoestrogens In Cultured Mammalian Cells. Int J  Cancer 2003 105, 312-320. Phytoestrogens, such as Genistein and Dadzein, are responsible for the mutation of genes in mammals.

2004
Unfer V and others. Endometrial effects of long-term treatment with phytoestrogens randomized, double blind, placebo-controlled study. Fertil Steril 2004 Jul;82(1):145-8. Women treated with soy phytoestrogens for 5 years were more likely to suffer from endometrial hyperplasia than those treated with a placebo.
2004 
Grace P and others. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancerand nutrition-norfolk. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):698-708. Women who had high concentration of Phystoestrogens were more likely to be at risk for breast cancer.

2005
Chen AC and others. Genistein Inhibits Intestinal Cell Proliferation in Piglets. Pediatric Research 2005, Vol. 57, No. 2, 192-200. Three groups of piglets were fed either sow milk replacer, sow milk replacer with small amounts of genistein and soy milk replacer with large amounts of genistein. The study found that those piglets who had consumed the large and small amounts of genistein had suffered from “reduced enterocyte proliferation and migration.”
Note: Enterocytes are cells which make up most of the inner surface of the intestine.

2005
Wood, C and others. Adrenocorticol Effects of Oral Estrogens and Soy Isoflavones in Female Monkeys. The Journal of Clinical Endocrinology and Metabolism 2005, Vol. 89 No. 5, 2319-2325. Three groups of female monkeys were fed either isoflavone depleted soy protein, soy protein with isoflavones or isoflavone depleted soy protein with conjugated equine estrogens, for 36 months. The group of monkeys fed the soy protein with isoflavones “had significantly lower adrenal weight… These findings suggest that long term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state.”

2006
Doerge D and others. Lactational transfer of the soy isoflavone genistein, in Sprague-Dawley rats consuming dietary genistein. Reprod Toxicol 2006 Apr;21(3):307-12. The study shows that small amounts of genistein are present in the milk of mothers who consumed the substance.

2006
Etcheverry P and others. Effect of Beef and Soy Proteins on the Absorption of Non-Heme Iron and Inorganic Zinc in Children. J Am Coll Nutr. 2006 Feb;25(1):34-40. Children who consumed beef meal had a “significantly greater” ability to absorb zinc and iron than those who consumed soy meal.
2006
Glover A and others. Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression. Journal of Endocrinology (2006) 189, 565-573. “Adult males, fed a high phytoestrogen diet for 3 days, demonstrated significantly reduced fecundity… lipid peroxidation of epididymal sperm was significantly increased in animals fed a high phytoestrogen diet for 3 days. Disruption of the steroid regulation of the epididymis by phytoestrogens may alter its function, resulting in decreased quality of sperm, and thereby reducing fecundity.”
2006
Milerova J and others. Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters. Clin Chem Lab Med 2006;44(2):171-4. Small differences in the amount of soy phytoestrogen consumed had moderately varying negative effects on the function of the thyroid gland.

2007
Jefferson W and others. Disruption of the female reproductive system by the phytoestrogen genistein.Reproductive Toxicology (2007) 23( 3), 308-16. Different amounts of Genistein fed to rats had adverse effect on the ovaries and estrogen cycle. Twenty five milligrams per kilogram caused lessened fertility and complete infertility was seen at fifty milligrams per kilogram. The offspring of females who consumed twenty five milligrams per kilogram of genistein were shown to have a larger number of multi-oocyte follicles(cysts), than those whose mothers had not, showing us that the effects of genistein can be carried for multiple generations. “Thus neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood.”

2007
Rachon D and others. Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. Maturitas 2007 Jun 20;57(2):161-70. “High dose consumption of commercially available preparations containing daidzein or puerarin may expose women with an intact uterus to the risk of endometrial hyperplasia.”
2007
Goodin S and others. Clinical and biological activity of soy protein powder supplementation in healthy male volunteers. Cancer Epidemiol Biomarkers Prev 2007;16:829–33. Twelve men 18 years or older were fed 56 grams of pure soy per day for 28 days. Over the 28 days the men experienced a 19% drop in serum testosterone.

2008
Chavarro J and others. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Human Reproduction 2008, Vol. 23. No. 10, 2584-90. Those men who consumed considerable amounts of soy food had lower sperm concentration. These findings stayed consistent with “age, abstinence time, body mass index, caffeine and alcohol intake and smoking.”

2009
Eustache F and others. Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility. Environmental Health Perspec 2009 Aug;117(8):1272-9. “Chronic exposure to a mixture of a dose of phytoestrogen equivalent to that in the human diet and a low dose… of a common anti-androgenic food contaminant may seriously affect the male reproductive tract and fertility.”

2009
Jefferson W and others. Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system. Environmental Health Perspective 2009 Dec;117(12):1883-9. When female newborns are exposed genistin, (the glycosylated form of genistein), it can cause harm to the reproductive system. This harm took the form of “delayed vaginal opening… abnormal estrous cycles, decreased fertility, and delayed parturition.”
2009
Pastuszewska B and others. Nutritional value and physiological effects of soya-free diets fed to rats during growth and reproduction. J Anim Physiol Anim Nutr (Berl). 2008 Feb;92(1):63-74. The groups of rats fed egg and milk protein, instead of soy, showed superior reproductive performance.

2010
Sosic-Jurjevic, B and others. Suppressive effects of genistein and daidzein on pituitary-thyroid axis in orchidectomized middle-aged rats. Experimental Biology and Medicine 2010 May;235(5):590-8. Two groups of middle-aged rats were fed 10 milligrams per kilo of either Dazein or Genistein for three weeks and a third group was fed regular feed. “This study provides…direct evidence that (Genistein and Dadzein) can induce microfollicular changes in the thyroid tissue and reduce the level of thyroid hormones…”

2010
Yu C and others. Maternal exposure to daidzain alters behavior and oestrogen receptor alpha expression in adult female offspring. Behavioral Pharmacology May 2010. “Maternal exposure to daidzein has a masculinisation effect on memory and social behavior.”

2010
Ward H and others. Breast, colorectal, and prostate cancer risk in the European Prospective Investigation intoCancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition 2010 Feb;91(2):440-8. “Dietary phytoestrogens may contribute to the risk of colorectal cancer among women and prostate cancer among men.”

2010
Cimafranca M and others. Acute and chronic effects of oral genistein administration in neonatal mice. Biology of Reproduction 2010 Jul;83(1):114-21. This study was conducted in order “to develop a mouse model that more closely mimics the oral genistein exposure and total serum genistein concentrations observed in soy formula-fed infants.” Baby mice were fed soy formula until the fifth day after birth. The results showed that the “genistein treatment caused increased relative uterine weight and down-regulation of progesterone receptor in uterine epithelia. Estrogenic effects of genistein were also seen in the neonatal ovary and thymus, which had an increase in the incidence of multioocyte follicles (cysts) and a decrease in thymic weight relative to body weight, respectively. The increased incidence of MOFs persisted into adulthood for neonatally treated genistein females, and estrous cycle abnormalities were seen at 6 mo of age.”

2010
Cedarroth C and others. Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.Molecular and Cellular Endocrinology 2010 Jun 10;321(2):152-60. Two groups of male mice were fed diets either containing large amounts of soy or no soy at all. The results showed “that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a small decrease in sperm count and fertility.”

2010
Balkrishnan B and others. Transplacental Transfer and Biotransformation of Genistein in the human placenta.Placenta 2010 June;31(6):506-511. Genistein has the ability to come through the placenta of healthy human fetuses.

Click here to read the entire article with studies dating back to th 1950’s

Sensitive to sugar, diabetic, or just cutting it out of your diet? Glycemic Index & Load Chart (White Rice is worse than a can of Cola!!!)

The glycemic index (GI) is a ranking of carbohydrates on a scale from 0 to 100 according to the extent to which they raise blood sugar levels after eating. Foods with a high GI are those which are rapidly digested and absorbed and result in marked fluctuations in blood sugar levels. Low-GI foods, by virtue of their slow digestion and absorption, produce gradual rises in blood sugar and insulin levels, and have proven benefits for health. Low GI diets have been shown to improve both glucose and lipid levels in people with diabetes (type 1 and type 2). They have benefits for weight control because they help control appetite and delay hunger. Low GI diets also reduce insulin levels and insulin resistance.

The glycemic load of a food tells how much eating that food raises blood glucose. It is a similar concept as the glycemic index, except it takes serving sizes into account. The formula is to take the number of grams of carbohydrate in the serving, multiply by the glycemic index, and divide by 100. Theoretically, if a food has glycemic load of one point, it would raise the blood sugar as much as one gram of glucose.

An awareness of foods’ Glycemic Index can help you control your blood sugar levels, and by doing so, may help you prevent heart disease, improve cholesterol levels, prevent insulin resistance and type-2 diabetes, prevent certain cancers, and achieve or maintain a healthy weight. A substantial amount of research suggests a low GI diet provides these significant health benefits.

After we eat carbohydrate-rich foods, our digestive process breaks them down and turns them into glucose, which enters bloodstream. (Since most proteins and fats are not turned into glucose , they have much less of an immediate effect on our blood sugar). Glucose in the bloodstream triggers the production of insulin, a hormone that helps glucose get into cells where it can be used for energy. Once our immediate energy needs have been met, extra glucose still remaining in the bloodstream will be stored in our muscles and liver for later use. If our muscle and liver stores of glucose are full, but we still have extra glucose floating around in our blood, then our body will store this excess sugar as fat.

Food Glycemic Index One Serving Glycemic Load
Coca-Cola 63 250ml 16
Gatoraide 78 250ml 12
Instant Oatmeal 83 250ml 30
Cornflakes 93 250ml 23
Quinoa 53 150ml 13
White Rice 89 150ml 43
Brown Rice 50 150ml 16
Apple 39 120ml 6
Banana 62 120ml 16
Grapefruit 25 120ml 3
Orange 40 120ml 4
Pear 38 120ml 4
Prune 29 60ml 10
Raisins 64 60ml 28
Watermelon 72 120ml 4
Peanuts 7 50ml 0
Black Beans 30 150ml 7
Carrots 35 80ml 2
Boiled White Potato(average) 82 150ml 21
Sweet Potato 70 150ml 22
Bread – French baguette 95 1oz.
Cereal Cheerios General Mills 95 1 cup, 1oz.
Cereal Rice Chex General Mills 89 1 1/4 cup, 1oz.
Cherries 22 10 large, 3oz.
Dark Chocolate(60%+ cocoa) 22
Crackers – saltine 72
Tofu frozen dessert low fat 115  1/2 cup, 2 ozs
Dates, dried 103  5 or 1.4ozs
Parsnips, boiled 97  1/2 cup, 2.5 ozs.
Sweet potato, peeled, boiled 54 1/2 cup mashed, 3 ozs.
White bread 70 1 slice or 1oz
Whole wheat bread 69 1 slice or 1oz
French fries 75
Grapenuts Cereal 75  30g  16
Pineapple, raw 66  120g  6
Ocean Spray Cranberry juice cocktail 68  250ml  24
Beef steak, battered, fried, lean & fat eaten 50  250ml  3.6

A food is generally considered to have a high GI if it is rated above 60.

Individuals who have problems with maintaining proper blood sugar levels should restrict their selection to foods with a GI of 40 or less. These include those who have low blood sugar (hypoglycemia) and high blood sugar (hyperinsulemia) as well as those who have a high sensitivity to sugar. Sugar includes not just simple sugars, honey and maple syrup but also fruits, fruit juices, starchy vegetables and grain products or foods with a high glycemic index.

FYI…..Average GI of beer = 110.

Why doesn’t the GI chart include things like beef, chicken, fish, nuts, seeds, avocadoes, and berries? These foods contain no carbohydrate, or so little that their GI cannot be tested according to the standard methodology. Bear in mind that the GI is a measure of carbohydrate quality. Essentially, these types of foods, eaten alone, won’t have much effect on your blood glucose levels.

Beach Almond – use it for: liver diseases, dermatitis, dysentery, diarrhea & cancer

Terminalia_catappa 2

Beach almond, or Terminalia catappa, is a tropical deciduous tree that produces an almond-like edible nut. Traditional healers use the leaves to treat hepatitis and other liver diseases, dermatitis, dysentery, diarrhea and cancer. Active ingredients include flavonoids, tannins, saponins and sterols, and the plant has antioxidant, anti-inflammatory and liver-protective properties. A study by S. Kinoshita and colleagues published in the November 2007 issue of “Phytomedicine” tested a leaf extract on animals with induced liver damage. The study found that the tannin known as corilagin scavenged free radicals and reduced oxidative damage in the liver, thereby repairing and protecting liver tissue. This study supports the traditional use of the plant in treating liver diseases and its ability to repair liver damage. Consult a health care professional before using this herb, since the long-term effects are not known. Do not use during pregnancy or breastfeeding.

Good night’s sleep linked to happiness

sleep-image-001“The team found that, as expected, having a more positive general outlook on life was associated with improved sleep quality. However, they found that the more reactive or fragile a participant’s positive emotions were in relation to external events, the more their sleep was impaired, especially for individuals high in positivity to begin with.”  Read more

Caveman or Palaeolithic Diet by Dr Ananya Mandal, MD

“Palaeolithic or the caveman diet is also called the Stone Age diet, and hunter–gatherer diet. The basic premise of this diet is inclusion and consumption of foods that have been assumed to have been available to humans before agriculture was established.

The Palaeolithic period and its food

The Palaeolithic period existed nearly 2.5 million years ago. This was the age when humans first started to use stone tools. The period ended with the advent of agriculture approximately 10,000 years ago.”

The foods that are thought to have been available during this period included wild-animal source foods and uncultivated-plant source foods. These included:-

  • lean meat
  • fish
  • eggs
  • vegetables
  • fruits
  • roots and tubers
  • nuts

There was no use of agriculture produce like:-

  • grains
  • legumes and pulses
  • dairy products like milk, butter, cheese etc.
  • salt
  • sugar
  • processed oils

Celicac (Coeliac) Disease Symptoms

“…The presentation of celiac disease may be varied with a wide range of severity of the symptoms. This makes diagnosis a challenge based on symptoms alone. Research suggests that diagnosis usually takes around 10 years after the appearance of first symptoms.” Read more

General symptoms of celiac disease

Broadly found the symptoms and signs of celiac disease include:–

  • Iron-deficiency anaemia and other or unspecified anaemia
  • Anorexia
  • Weight loss
  • Abdominal distension/bloating
  • Abdominal pain
  • Flatulence
  • Vomiting
  • Diarrhoea
  • Constipation and irregular bowel habits
  • Short stature/growth failure and failure to thrive
  • Irritability, mood swings and depression/bipolar disorder
  • Alopecia
  • Osteoporosis
  • Recurrent aphthous stomatitis
  • Amenorrhoea/recurrent abortion and infertility
  • Hypertransaminaseaemia and abnormal liver biochemistry

Associated features and diseases

There are several associated features and diseases as well. These include:-

  • Dermatitis herpetiformis
  • Irritable bowel syndrome
  • Liver disorders
  • Microscopic colitis
  • Rheumatological disorders including Rheumatoid arthritis
  • Crohn’s disease and Inflammatory bowel disease
  • Type 1 diabetes – the prevalence of celiac disease in people with type 1 diabetesis 1.4 to 8.2% in children, 0.3 to 11.3% in adults and 1.7 to 5.7% in combined child and adult populations.
  • Autoimmune thyroid disease
  • Down syndrome
  • Epilepsy
  • Infertility
  • Lymphoid malignancy
  • Autoimmune Myocarditis
  • Sjögren’s syndrome
  • Sarcoidosis
  • Turner syndrome
  • Chronic thrombocytopenic purpura
  • Polyneuropathy

Pure Inspiration

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